Finally, to determine whether these T cells that were hyperresponsive ex vivo would have any in-vivo effect in a disease model, we adopted a model of myelin oligodendrocyte glycoprotein (MOG) peptide-induced experimental autoimmune encephalomyelitis (EAE) following the adoptive transfer of CD4+ T cells38. Here, CD4 is linked to experimental autoimmune encephalomyelitis.