FLI1 and neoplasm: Also, a small molecule (YK-4-279) that binds to the disordered EWS-FLI1 fusion oncoprotein associated with Ewing’s sarcoma family tumors inhibited direct binding to RNA helicase A (RHA)8, a functional partner of EWS-FLI1 in tumor cells8, and altered RHA-dependent protein interactions and RNA splicing9.