Although scrapie infection does not seem to induce a specific immune response to the agent (a misfolded self-antigen) (Prusiner, 1982) or grossly affect the immunological function of the lymph node (Heikenwalder et al., 2005), 75 genes were significantly differentially-expressed by 10 days after SSBP/1 infection, in comparison to uninfected brain homogenate of the same PRNP genotypes. This evidence concerns the gene PRNP and infection.