S100A8 and infection: Furthermore, the results of a number of recent clinico-epidemiological studies have shown that infection with H. pylori strains carrying Western CagA with two or more EPIYA-C segments is a greater risk for the development of gastric carcinoma than is infection with H. pylori carrying CagA with a single EPIYA-C segment15, 16, 17, 18, 19, 20.