S100A8 and gastric cancer: A number of clinico-epidemiological studies have shown that H. pylori strains harboring two or more CagA EPIYA-C segments are associated with gastric cancer15, 16, 17, 18, 19, 20, although several studies failed to show a clear association between the number of EPIYA-C segments and gastric cancer, most probably due to small sample sizes31, 32.