MALT1 and diffuse large B-cell lymphoma: The first indication that Malt1 inhibition might be a promising strategy to treat human diseases came from two studies in 2009 which reported a preferential cytotoxicity of the MALT1 inhibitor z-VRPR-fmk on a subtype of cell lines derived from diffuse large B-cell lymphoma (DLBCL) [74, 75].