Using an RNAi screen on ABC DLBCL cell lines, Ngo and colleagues demonstrated that these cell lines, which have combined mutations in MyD88 and either the CD79 or CARMA1 proteins, heavily depend on NF-κB activation via CARMA1, BCL10 and MALT1 for their survival and proliferation [82]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.