CARMA1- or MALT1-deficient mice are fully protected from induction of experimental autoimmune encephalomyelitis (EAE) by immunization with myelin oligodendrocyte glycoprotein (MOG) [14, 98, 99], and treatment of mice with the MALT1 inhibitor mepazine attenuates onset and progression of the disease [100]. Here, MALT1 is linked to experimental autoimmune encephalomyelitis.