NUCLEOLIN and neoplasm: The fluorescent enhancement of CL1-5 tumor with targeting AS1411-DA-AuNPs injection of mouse A was 172% in comparison to non-targeting DA-AuNPs injection of mouse B. Overall, the in vivo experiments in Fig. 8 have showed that the AS1411 aptamer conjugated with fluorescent gold nanoparticles can be used for selectively targeting nucleolin highly expressed CL1-5 tumor, and the strong fluorescence of AS1411-DA-AuNPs was sufficient to contrast the tumor lesions.