Furthermore, we found positive correlations between expression of some caspases and adverse clinicopathological features: procaspase-8 correlated with both clinical and pathological T stages, cleaved caspase-8 correlated with preoperative serum PSA, and caspase-7 correlated with Gleason score and the presence of lymph node metastasis. This evidence concerns the gene CASP8 and metastatic malignant neoplasm in the lymph nodes.