Although increased RPS11 protein expression levels in either primary or secondary GBM tumors were associated with an increased hazard of death (Primary: HR = 3.95, p = 0.005; Secondary: HR = 6.85, p = 0.05), the prognostic significance was markedly enhanced when analysis was performed in newly diagnosed GBM (HR = 9.29, p<0.001) or newly diagnosed primary GBM (HR = 11.46, p<0.001). Here, RPS11 is linked to glioblastoma.