Then, we re-analyzed high throughput RNA-sequencing data of the GBM cohort of The Cancer Genome Atlas (TCGA, https://tcga-data.nci.nih.gov/tcga/tcgaCancerDetails.jsp?diseaseType=GBM&diseaseName=Glioblastoma%20multiforme) and found that TREM2 expression was significantly increased in glioma tissues compared with normal brain tissues (Figure 1B, P < 0.001). The gene discussed is TREM2; the disease is glioblastoma.