Furthermore, gene set enrichment analysis (GSEA) using The Cancer Genome Atlas (TCGA) dataset showed that TREM2 was positive related with Kyoto Encyclopedia of Genes and Genomes (KEGG) apoptosis, Cromer metastasis and KEGG chemokine pathways, which was further validated in glioma cells with TREM2 silenced. This evidence concerns the gene TREM2 and glioma.