After 24 h of incubation, compared with the NC cells (104 ± 1 cells and 120 ± 1 cells), both TREM2-RNAi-U87 and TREM2-RNAi-U373 glioma cells showed significantly decreased migratory ability (46 ± 1 cells and 52 ± 1 cells, respectively, both P < 0.001; Figure 4B). Here, TREM2 is linked to glioma.