WWP1 and hepatocellular carcinoma: Our findings showed that WWP1 was abnormally elevated in primary HCC tissue specimens compared to normal hepatic tissues, and overexpression of WWP1 was significantly correlated with larger tumors, poorly differentiated histological grade, advanced TNM stage, vascular invasion, lower OS and PFS times, and poor prognosis in a cohort of 149 patients who had undergone surgery for primary HCC.