It would be interesting to find out whether a E3 ligase of the homologous to the E6P carboxyl terminus (HECT) family, HERC5, which catalyses ISG15ylation of a panel of targets, cooperates with UbcH8 in ISG15ylation in NPC cells, as E6AP, an E3 ubiquitin ligase of HECT family, cooperates with UbcH8 in ubiquitylation [19]. The gene discussed is UBE3A; the disease is nasopharyngeal carcinoma.