TNFSF10 and pancreatic adenocarcinoma: Additionally, knockdown of Bcl-xL by siRNA significantly increased the TRAIL sensitivity of AsPC-1 and Panc-1 cell lines (Figure 5), which is consistent with a previous report that demonstrated that Bcl-xL protects pancreatic adenocarcinoma cell lines from apoptosis via CD95/DR signaling [38].