The relationship between Bcl-xL expression and TRAIL sensitivity and the specificity of ABT-263 and ABT-199 suggest that Bcl-xL is responsible for TRAIL resistance in human pancreatic cancer cells and that inhibition of Bcl-xL by ABT-263 is a useful way to sensitize human pancreatic cancer cells to TRAIL. Here, BCL2L1 is linked to pancreatic neoplasm.