PTEN and invasive ductal breast carcinoma: To exclude cell type-dependence, we examined two additional breast cancer cell lines phenotypically different from SUM190 (inflammatory breast cancer cell line, invasive ductal carcinoma, ER-PR-HER2−/+), including MCF-7 (invasive ductal carcinoma, ER+PR+) and Cama-1 (adenocarcinoma, ER+PR−, oncogenic mutations in PTEN and p53, in-frame mutation in E-cadherin gene) [27].