To confirm that that cellular effects observed after ZFAS1 silencing in CRC cells are not a consequence of reduced SNORD12 expression, we evaluated effects of ZFAS1 silencing on SNORD12 levels and found that there is just a minor change in SNORD12 expression in ZFAS1-silenced cells (Supplementary Figure S2A). The gene discussed is ZFAS1; the disease is colorectal carcinoma.