The mixed grade carcinoma IC499, predominantly grade 1 with foci of grade 2/3, may represent a LGSC that has progressed to high grade as it was found to carry an EIF1AX mutation (along with NRAS and TP53 mutations), which have only been reported in the 316 ovarian carcinomas assessed by the TCGA [12] in a case later reviewed as likely LGSC (TCGA-61-2095) [13]. The gene discussed is TP53; the disease is ovarian carcinoma.