This differential effect did not appear to be due to enhanced in vivo inhibition of phospho-targets, reduced cell surface CD44 expression (known to correlate with MOC cell aggressiveness [20]), reduced tumor cell proliferation, reduced tumor vascularization or expression of angiogenic cytokines or enhanced tumor cell apoptosis, all of which were similarly or more significantly altered by MEK inhibition. This evidence concerns the gene MAP2K7 and neoplasm.