TFRC and hyperinsulinemic hypoglycemia, familial, 4: Similar to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -associated inhibition of mitochondrial complex I, mitochondrial dysfunction in iPLA2β deficiency could cause both a rise in ROS and a depletion of ATP; these two events have been shown to augment the binding activity of IRPs [22, 23] that control the expression of DMT1 + IRE and/or TfR1 and the subsequent increase in iron content [19].