To clarify the mechanism underlying iron accumulation in the brains of iPLA2β-KO mice, we investigated the expression of molecules that are involved in iron homeostasis, including DMT1 and IRPs, in the brains of iPLA2β-KO mice as well as in PLA2G6 knockdown (KD) SH-SY5Y human neuroblastoma cells. This evidence concerns the gene PLA2G6 and neuroblastoma.