In colorectal cancer cells, NDRG2 suppresses the expression of GLUT1 as well as of other glucose transporters and catalytic enzymes involved in glycolysis and glutaminolysis, including hexokinase 2 (HK2), pyruvate kinase M2 isoform (PKM2), lactate dehydrogenase A (LDHA), the glutamine transporter ASC amino acid transporter 2 (ASCT2) and glutaminase 1 (GLS1) [97]. The gene discussed is HK2; the disease is colorectal cancer.