In summary, this study revealed that the loss of miR-192 expression exerts wide ranging effects on cell proliferation and cell anchoring by activating DHFR and by molecular cross talk between ITGAV, ITGB1, ITGB3, and CD47 in the leptomeningeal dissemination of medulloblastoma. The gene discussed is ITGB1; the disease is medulloblastoma.