Notably, many genes known to be associated with worse outcomes in CN-AML/AML were up-regulated, including WT1 [12], ITPR2 [15], MAPKBP1 [16], BAALC, ERG [11], MN1 [23], SPARC [24], DNMT3B [13], MSI2 [25], GATA2 [26], SOCS2 [27], CXXC5 [18] and MLLT11 [28]. Here, CXXC5 is linked to acute myeloid leukemia.