More ATP1B1high expressers also carried FLT3-ITD, and several known unfavorably prognostic biomarkers were up-regulated in CN-AML (ERG, BAALC, MN1, WT1, DNMT3B, TCF4, ITPR2, DNMT3A, SPARC, CXXC5, MAPKBP1 and MIR155HG) (See Table 1 and Figure 2). This evidence concerns the gene CXXC5 and acute myeloid leukemia.