Considering that expression of both DNMT3A and DNMT3B correlated positively with ATP1B1 expression, we carried out a genome-wide differential analysis to identify differences in the methylation patterns between ATP1B1high and ATP1B1low expressers based on a TCGA AML cohort of 74 CN-AML patients. This evidence concerns the gene ATP1B1 and acute myeloid leukemia.