The mTOR protein complex functions as a serine/threonine kinase that is mainly activated by the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway and plays a pivotal role in control of cell cycle, proliferation and cellular survival both in normal renal tubules and in renal cell carcinoma [5] [6] [7]. The gene discussed is MTOR; the disease is hereditary clear cell renal cell carcinoma.