UBE3A and infection: E6AP knockdown in stably transduced HL60 cells with shE6AP lentiviral particles restored MNT protein levels post-4-days infection (Figure 6a) and triggered myeloid differentiation as shown by enhanced cd11b positivity; 42.88% cells showed cd11b expression compared to 5.85% in shCtrl infected cells (Figure 6b; representative FACS 2D-dot plot is shown in figure S7.a).