SLC27A4 and ichthyosis: In this study a genome-wide association analysis for autosomal recessive ichthyosis in Great Danes showed a highly significant peak on chromosome 9 near SLC27A4. Sequencing of the genomic DNA of SLC27A4 revealed the exonic variant SLC27A4:g.8684G>A, 52 bp downstream of the beginning of exon 8, which was proposed to create a new and strong splice acceptor site, and thus an in-frame loss of 54 bp in the SLC27A4 transcript of ichthyosis-affected puppies.