In keeping with the hypothesis that PKCβ mediates CCB-induced aortic aneurysm exacerbation in Marfan mice, treatment with enzastaurin led to a significant reduction in ascending aortic growth in amlodipine-treated animals (treatment effect: p < 0.0001), with the magnitude of effect being significantly greater in Marfan mice (interaction effect: p < 0.0001, Figure 4C). Here, PRKCB is linked to aortic aneurysm.