ACE and Marfan syndrome: Prior studies in mouse models of Marfan syndrome and related disorders have shown that β-blockers (e.g., propranolol) (Habashi et al., 2006; Gallo et al., 2014) or angiotensin converting enzyme inhibitors (ACEi, e.g., enalapril) (Habashi et al., 2011) achieve a relatively modest inhibition of aortic aneurysm growth and fail to preserve aortic wall architecture when compared to the ARB losartan, despite an equivalent reduction in blood pressure.