Furthermore, and considering our previous results in C. elegans model of MJD upon VPA treatment, we also assessed the mRNA levels of GADD45α and BIM, two genes related to stress resistance and apoptosis regulation, respectively [23–26], in the cerebellum of CMVMJD135 mice, where a trend towards an increase upon VPA acute treatment was also observed (Fig 1B). This evidence concerns the gene BCL2L11 and Machado-Joseph disease.