In cardiac and skeletal muscle, the product of MYOZ2 appears to influence the expression of calcineurin, which is required for the key processes of myocyte differentiation and conversion to the slow (oxidative) muscle phenotype and plays an important role in hypertrophic cardiomyopathy and skeletal muscle fiber differentiation[54]. The gene discussed is MYOZ2; the disease is hypertrophic cardiomyopathy.