Indeed, heterotetrameric Kv2.1/Kv9.3 channels are involved in hypoxic pulmonary artery vasoconstriction [16,17], mutations in Kv8.2 have been associated with an inherited retinal dystrophy [18] and epilepsy susceptibility [19] and recently the involvement of Kv6.4 in a fast motor neuron biophysical signature has been demonstrated [20]. This evidence concerns the gene KCNB1 and epilepsy.