In tauopathies, where the densely packed microtubules in neurite structures become destabilised and tau protein misfolds to form NFTs, diffusion MRI techniques that use biophysical models of tissue (Vestergaard-Poulsen et al., 2011, Jespersen et al., 2012, Hansen et al., 2011, Wang et al., 2013) may have higher specificity to changes in tissue cytoarchitecture and the pathological processes of tau accumulation. This evidence concerns the gene MAPT and tauopathy.