Infusion of angiotensin II in rats led to increases in vascular endothelial growth factor (VEGF), which is protective for RGC loss in the rat glaucoma model [72,73,74] losartan treatment blocks the increase in VEGF [75], argues against a direct neuroprotective effect of AT1R inhibition by losartan on RGCs themselves. This evidence concerns the gene VEGFA and glaucoma.