Signaling through AT1R upregulates expression of thrombospondin 1, a potent activator of TGFβ [66,67,68,69] in mouse glaucoma sclera showed increased thrombospondin, a potent activator of TGFβ, which was somewhat less in losartan-treated than in water-treated glaucoma sclera. The gene discussed is AGTR1; the disease is glaucoma.