BCL2 and systemic lupus erythematosus: Consistently, IL-17 has been implicated in modulating the expression levels of prosurvival Bcl-2 family proteins, including Bcl-2 (B-cell lymphoma 2) [52] and Bfl-1/A1 (Bcl-2 family member) in some autoimmune diseases such as systemic lupus erythematosus [53].