There are some examples of genetic research on JIA outcomes, including a study that suggests that the MIF-173 polymorphism (MIF-173∗C allele) is a predictor of poor outcome in systemic-onset JIA [22], another study that found SNPs in the IL6 gene associated with pain [14] and a correlation between TGF-b1 gene codon 25 genotypes and early radiological damage [14], and, in the ERA subtype, a publication suggesting that the presence of HLA-DRB1∗08 predicts failure to attain disease remission [23]. This evidence concerns the gene TGFB1 and systemic-onset juvenile idiopathic arthritis.