In contrast to this finding, human IL-10 producing CD24highCD27high Breg cells (found to suppress monocytes in an IL-10 dependent manner) were increased in patients with rheumatoid arthritis, SLE, and multiple sclerosis when compared to healthy individuals, suggesting this increase to be compensatory, aiming (with little success) to maintain self-tolerance [19]. Here, IL10 is linked to systemic lupus erythematosus.