INS and obesity due to melanocortin 4 receptor deficiency: For comparison, study conducted by Iacobellis et al. (2005) has proven that in an Italian cohort of obese patients, in which the MetS IDF criteria were also used as a discriminator of complicated and uncomplicated obesity in combination with assessment of such parameters as uric acid, fibrinogen, and insulin levels, prevalence of this phenomenon was higher and amounted to 27.5% despite the fact that selection criteria were stricter than those in our study [12].