Within the framework of this study, genotype distribution and alleles frequency of the leptin (019G polymorphism), leptin receptor (LEPR) (Q223R polymorphism), and adiponectin receptor (T45G and G276T polymorphisms) were analyzed in MUO and MHO as these genes potentially might be responsible for the development of obesity and metabolic disorders. This evidence concerns the gene LEP and Other metabolic disease.