Within the framework of this study, genotype distribution and alleles frequency of the leptin (019G polymorphism), leptin receptor (LEPR) (Q223R polymorphism), and adiponectin receptor (T45G and G276T polymorphisms) were analyzed in MUO and MHO as these genes potentially might be responsible for the development of obesity and metabolic disorders. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.