LEPR and metabolic disease: However, in women with AO with and without MetS/metabolic disorders (general cohort), carriers of the 223R allele of the LEPR gene, leptin levels were higher than those in individuals with the Q223Q genotype (57.124 ± 0.370 ng/mL and 46.301 ± 2.752 ng/mL, resp.; p = 0.030).