Furthermore, in women with AO and metabolic disorders with the R223R genotype, leptin levels were higher than those in women, carriers of the 223Q allele of the LEPR gene (60.744 ± 5.581 ng/mL and 47.521 ± 3.243 ng/mL, resp.; p = 0.045). The gene discussed is LEPR; the disease is metabolic disease.