Previously nonobese diabetic (NOD) HIIEα-HSP60 Tg mice, in which HSP60 is driven by the MHC class II-Eα (HIIEα) promoter, achieved HSP60 expression specifically in the thymus and bone marrow and suppressed susceptibility to autoimmunity induced DM [31]. This evidence concerns the gene HSPD1 and Autoimmunity.