On the other hand, EGFR-AKT signaling is likely tissue specific and context dependent, as loss of PARK2 have been found to increase or decrease the activity of EGFR-AKT, and subsequently, promote or hinder neuronal survival, adding a complex layer to the conflicting association between PD and different cancers [73, 77]. The gene discussed is AKT1; the disease is Parkinson disease.