DNMT1 and cutaneous melanoma: However, when we analyzed an RNA-seq dataset obtained from a collection of 278 cutaneous melanoma tissue samples (TCGA), we observed that DNMT1 expression levels were slightly, albeit significantly, lower in samples displaying a higher CGAS (Fig. 2b; p = 0.0413), even when adjusting for cell proliferation rates (Additional file 5: Figure S4).