Consistently, melanoma tissue samples with a higher CGAS also showed significant down-regulation of three out of out representative ICCG genes (CDCA7L, CDCA7, ASF1B, and CCNB1), which were selected from the original ICCG group on the basis of highest anti-correlation significance and variation coefficient in the 45-MelCells analysis (Fig. 2a, b). This evidence concerns the gene CCNB1 and melanoma.