This effect may be important in the initial phase of inflammatory and neuropathic pain but may be superimposed by the changes in the pattern of expression of TNFR-1 and TNFR-2 after nerve injury and explain the effects of TNFR-1 and TNFR-2 seen in other studies, especially after nerve injury [6, 25]. Here, TNFRSF1B is linked to injury.