HRASLS3/AdPLA is expressed predominantly in white adipose tissue (WAT), and also to a lesser extent in brown adipose tissue [13, 14], where it is a major regulator of lipolysis and is crucial for the development of obesity, as seen in an Hrasls3−/−/AdPLA−/− mouse model [13]. Here, PLAAT3 is linked to obesity due to melanocortin 4 receptor deficiency.