PLAAT4 and neoplasm: HRALS4 was identified by three separate groups in 1998 [35], 2000 [36], and 2001 [37] as a retinoid-inducible anti-proliferative/class II tumour suppressor gene that goes by the alternate names Tazarotene-induced protein 3 (TIG3), Retinoic acid receptor responder protein 3 (RARRES3), and Retinoid-inducible gene 1 (RIG1) (see Table 1 for all aliases).