However, since 3xTg-AD mouse model harbors mutations not only on APP and PS1 but also on tau genes and because splenomegaly or changes in cytokines and lymphocytes have not been yet reported in other AD mouse models such as APP or APP/PS1 transgenic mice, we cannot exclude the implication of tau mutation in splenic dysfunction37, 38. The gene discussed is APP; the disease is Alzheimer disease.