Canonical Pathways Analysis of the 553 genes identified hepatic fibrosis and hepatic stellate cell activation (P <1 × < 10−7), acute phase response signaling (P <1 × 10 −5), and HIF-1α signaling (P <1 × 10−4) as the most significantly enriched (Fig. 3a). Here, HIF1A is linked to fibrosis.