ANXA5 and ovarian cancer: To further confirm whether the growth inhibition of ovarian cancer cells was related to apoptosis, we evaluated the apoptotic effect of simvastatin on Hey and SKOV3 cells by Annexin-V FITC stain analysis, which detects the phospholipid phosphatidylserine (PS) translocation from the inner (cytoplasmic) leaflet of the cell membrane to the external surface in very early apoptotic cells.