BRAF and metastatic melanoma: However, the response rates observed with TMZ and lenvatinib in the present study are lower than a 61% objective response rate (44 of 72 patients) observed in patients with melanoma receiving a combination of ipilimumab and nivolumab [17], and lower than a 31.7% objective response rate (38 or 120 patients) observed in a phase 3 trial of nivolumab in patients with metastatic melanoma whose disease had progressed after previous treatment with ipilimumab, or treatment with ipilimumab and a BRAF inhibitor if their tumors harbored a BRAF V600E mutation [18].