Pathogenic MBD4 variants were found in 13/1536 (0.85%) and 10/6503 (0.15%) CRC cases and controls, respectively; likely non-pathogenic variants were present in 21/1536 (1.37%) and 24/6503 (0.37%) CRC cases and controls, respectively. This evidence concerns the gene MBD4 and colorectal carcinoma.