Moreover, like its upstream regulator, PI3K, Akt regulates the AREG-induced cancer cell migration of osteosarcoma and the expression of ICAM-1 at treatment with an Akt inhibitor (Akti) [61], can inhibit the AREG-induced migration and ICAM-1 up-regulation (Figure 4B–4D). Here, AKT1 is linked to osteosarcoma.