PDP1 and neoplasm: For instance, the trans-activation of the gene for PDH kinase isoform 1 (PDK1) by HIF-1 is induced in hypoxia [34]; the phosphorylation-induced activation of PDK1 by oncogenic mitochondrial Tyr kinases is under the control of tumor regulators Myc and HIF-1 [35], and an inhibitor of PDH kinase, dichloroacetate, negatively affects tumor growth, which correlates with PDH activation [6, 36, 37].