In view of lactate accumulation upon PDHC inhibition, the ability of cancer cells to extrude lactate faster through higher expression of SLC16A8, aided by SLC16A3 in U87 cells (Table 3), may also contribute to the higher resistance to the P-analogs of the glioblastoma vs HEK293 cell lines (Fig. 5, Table 2). Here, SLC16A3 is linked to cancer.