Generated by similar β- and γ-cleavages on amyloid-like protein 1 (APLP1, another member of the amyloid precursor protein [APP] gene family), which also includes APLP2 and APP), APL1β28 was recently reported to be a surrogate biomarker for AD with the use of mass spectroscopy56. This evidence concerns the gene APLP1 and Alzheimer disease.