HPD and cancer: Some amino acids were also reported as critical regulators of several cell signaling pathways in cell proliferation of cancer [45] gene_55049, gene_7239, gene_21618, gene_30065, gene_40340, gene_20744, and gene_48928 detected by RNA-seq in T were at least two times higher than those in WT, which encodes 4-hydroxyphenylpyruvate dioxygenase, methylcrotonyl-CoA carboxylase, arginine decarboxylase 2, glutamine-dependent asparagine synthase 1, methylenetetrahydrofolate reductase, methionine gamma-lyase, and lysine-ketoglutarate reductase, respectively.