Ki-67 proliferative index was scored using a progressive five-class scale from the less proliferative (score 0) to the more proliferative tumours (score 4): inferior to 2 % (score 0), from 2 to 5 % (score 1), from 6 to 10 % (score 2), from 11 to 20 % (score 3) and superior to 20 % (score 4). This evidence concerns the gene MKI67 and neoplasm.