CDH10 and lung cancer: In the functional assays using two lung cancer cell lines with high CDH10 expression (NCI-H522 and NCI-H1373) (Supplementary Fig. 5 a,b), CDH10 silencing using different shRNAs consistently resulted in a significant increase in cell proliferation (Supplementary Fig. 6 a,f) and soft-agar colony formation (Supplementary Fig. 6 g,h).