Human orthologs of for, KCNQ, Pde1C, phl, Pkc53E, rhea [58], fra [63], Nrx-IV [10], Pde11 [59], Pka-R2 [60] and RhoGAP68F [14] have been associated with alcohol dependence and/or alcohol consumption in human GWA studies. Here, PDE1C is linked to alcohol dependence.